(S)-2-(2-ethoxyethyl)piperazine → (S)-10-[3-(2-Ethoxyethyl)-piperazin-1-yl]-2-isopropyl-4H-3-thia-1,4,9-triazabenzo[f]azulene
Reaction equation
Cl.[CH:2]([C:5]1[S:14][C:13]2[NH:12][C:11]3[CH:15]=[CH:16][CH:17]=[CH:18][C:10]=3[N:9]=[C:8]([NH2:19])[C:7]=2[N:6]=1)([CH3:4])[CH3:3].[CH2:20]([O:22][CH2:23][CH2:24][C@H:25]1[CH2:30]N[CH2:28][CH2:27][NH:26]1)[CH3:21]>>[CH2:20]([O:22][CH2:23][CH2:24][C@@H:25]1[NH:26][CH2:27][CH2:28][N:19]([C:8]2[C:7]3[N:6]=[C:5]([CH:2]([CH3:4])[CH3:3])[S:14][C:13]=3[NH:12][C:11]3[CH:15]=[CH:16][CH:17]=[CH:18][C:10]=3[N:9]=2)[CH2:30]1)[CH3:21]Participants
3
Procedure
In a manner similar to that described in Example 300, combine 2-isopropyl-4H-3-thia-1,4,9-triazabenzo[f]azulene-10-ylamine hydrochloride (0.523 g, 1.77 mmol) and (S)-2-(2-ethoxyethyl)piperazine (0.561 g, 3.54 mmol) to obtain the title compound: mass spectrum (APCI): m/z =400.2 (M+1).
Sources & evidence
- ORD record
- ord-99406570a9b5441fb5a4be15a95427f0
- Source dataset
- uspto-grants-2008_06
- Patent number
- US07384934B2
Reaction notes
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