2-Methyl-5,10-dihydro-4H-thieno[2,3-b][1,5]benzodiazepine-4-thione → (S)-2-Methyl-1-[4-(2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulen-10-yl)piperazin-2-yl]-propan-2-ol

HRID 131512Notes

Reaction equation

HRID 131512 reaction equation
[CH3:1][C:2]1[S:11][C:10]2[NH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[NH:6][C:5](=S)[C:4]=2[CH:3]=1.[CH3:17][C:18]([OH:27])([CH3:26])[CH2:19][C@H:20]1[CH2:25][NH:24][CH2:23][CH2:22][NH:21]1>>[CH3:26][C:18]([OH:27])([CH3:17])[CH2:19][C@H:20]1[CH2:25][N:24]([C:5]2[C:4]3[CH:3]=[C:2]([CH3:1])[S:11][C:10]=3[NH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[N:6]=2)[CH2:23][CH2:22][NH:21]1

Participants

3

Reactant 2

HCID 210935012-Methyl-5,10-dihydro-4H-thieno[2,3-b][1,5]benzodiazepine-4-thioneHCID 45099480(S)-2-methyl-1-piperazin-2-yl-propan-2-ol

Product 1

HCID 136090357(S)-2-Methyl-1-[4-(2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulen-10-yl)piperazin-2-yl]-propan-2-ol

Procedure

In a manner similar to that described in Example 359, combine 2-methyl-4,9-dihydro-3-thia-4,9-diazabenzo[f]azulene-10-thione (0.574 g, 2.33 mmol) and (S)-2-methyl-1-piperazin-2-yl-propan-2-ol (0.369 g, 2.33 mmol) to obtain the title compound: mass spectrum (APCI): m/z=371.2 (M+1).

Sources & evidence

ORD record
ord-09c32a9c163447bf9358bfd9319139ee
Source dataset
uspto-grants-2008_06
Patent number
US07384934B2

Reaction notes

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