Water → HCID 69214914, compound

HRID 131579Notes

Reaction equation

HRID 131579 reaction equation
[Na].C[O:3][C:4]([C:6]1[C:14]2[C:13](=[O:15])[N:12]([CH3:16])[C:11](=[O:17])[N:10]([CH:18]([CH3:20])[CH3:19])[C:9]=2[S:8][C:7]=1[CH2:21][N:22]1[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[N:24]=[C:23]1S(C)(=O)=O)=[O:5].[OH2:35]>>[O:35]=[C:23]1[N:22]([CH2:21][C:7]2[S:8][C:9]3[N:10]([CH:18]([CH3:20])[CH3:19])[C:11](=[O:17])[N:12]([CH3:16])[C:13](=[O:15])[C:14]=3[C:6]=2[C:4]([OH:3])=[O:5])[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[NH:24]1

Participants

4

Reactant 3

HCID 962WaterHCID 5360545SodiumHCID 69211397HCID 69211397, compound

Product 1

HCID 69214914HCID 69214914, compound

Procedure

Sodium hydrogenocarbonate (0.55 g) was added to a suspension of the product from example 32 part b) (0.54 g) in water. The reaction mixture was heated at reflux for 17 h. The reaction mixture was washed with ethyl acetate and the aqueous layer was freezed dried to give the sub-title compound (0.7 g). MS(ES)(M++H) 415

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 17 h
  3. washThe reaction mixture was washed with ethyl acetate
  4. customthe aqueous layer was freezed dried

Sources & evidence

ORD record
ord-f153d00e713347b2bb4c2cbe5f3c8c83
Source dataset
uspto-grants-2008_06
Patent number
US07384950B2

Reaction notes

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