反应详情

温度

125 °C

A mixture of 5-iodo-1-isopropyl-1H-indazole (129c, 461 mg, 1.26 mmol), (1R,2S)-2-amino-1-phenylpropan-1-ol (286 mg, 1.89 mmol), copper (I) iodide (25 mg, 130 μmol), and cesium carbonate (1.45 g, 3.8 mmol) in butyronitrile (5 ml) was stirred at 125° C. for 2 h. Then the mixture was cooled to r.t., the inorganic material was removed by filtration and washed with ethyl acetete. The combined organic solutions were concentrated in vacuo, and the product purified by flash chromatography on silica gel (ethyl acetate/methanol). Yield 200 mg (51%) of a brown oil.

1. temperatureThen the mixture was cooled to r.t.
2. customthe inorganic material was removed by filtration
3. washwashed with ethyl acetete
4. concentrationThe combined organic solutions were concentrated in vacuo
5. customthe product purified by flash chromatography on silica gel (ethyl acetate/methanol)