Sodium Hydroxide → HCID 69308332, compound

HRID 131624Notes

Reaction equation

HRID 131624 reaction equation
C[O:2][C:3]([C:5]1[C:13]2[C:12](=[O:14])[N:11]([CH3:15])[C:10](=[O:16])[N:9]([CH2:17][CH:18]([CH3:20])[CH3:19])[C:8]=2[S:7][C:6]=1[CH2:21][C:22]1[C:23]([CH3:28])=[N:24][NH:25][C:26]=1[CH3:27])=[O:4].[OH-].[Na+:30]>C1COCC1.O.CO>[Na+:30].[CH3:27][C:26]1[C:22]([CH2:21][C:6]2[S:7][C:8]3[N:9]([CH2:17][CH:18]([CH3:20])[CH3:19])[C:10](=[O:16])[N:11]([CH3:15])[C:12](=[O:14])[C:13]=3[C:5]=2[C:3]([O-:4])=[O:2])=[C:23]([CH3:28])[NH:24][N:25]=1

Participants

6

Reactant 2

HCID 14798Sodium HydroxideHCID 16102861HCID 16102861, compound

Product 1

HCID 69308332HCID 69308332, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

Prepared from a solution of the product of step e) (19.0 g) and sodium hydroxide (2.52 g) in THF (400 ml), water (35 ml) and methanol (60 ml). After stirring at ambient temperature for 24 hours the precipitate was filtered off and washed with cold THF to give the sub-title compound as a white solid (17.2 g).

Workup

  1. filtrationwas filtered off
  2. washwashed with cold THF

Sources & evidence

ORD record
ord-a5a3e86c6a0f42519e7c6f3124c501eb
Source dataset
uspto-grants-2008_06
Patent number
US07384951B2

Reaction notes

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