Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1316250Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1316250
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>CS(C)=O.O=C([O-])[O-].[Cs+].[Cu][I].c1ccc(P(c2ccccc2)[c]23->[Fe+2]456789%10(<-[cH]([cH]->4[cH-]->52)[cH]->63)<-[cH]2[cH]->7[cH-]->8[c]->9(P(c3ccccc3)c3ccccc3)[cH]->%102)cc1>FC(F)(F)c1ccc(N2CCOCC2)cc1

Komponenten

9

Edukt 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

Produkt 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholineAusbeute 0 %HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholineAusbeute 0 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 14794698CID 14794698ReagenzHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)KatalysatorHCID 178420530HCID 178420530, VerbindungKatalysatorHCID 679Dimethyl SulfoxideLösungsmittel5×

Reaktionsbedingungen

Temperatur
30 °C

Aufarbeitung

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid-Phase beibehalten
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

Quellen und Nachweise

ORD-Eintrag
ord-19eabf46430844d19b25a20218565101
Quelldatensatz
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
Originallink
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