3-[(Dimethylamino)methyl]-4-methoxyaniline → N-[3-(Dimethylaminomethyl)-4-methoxyphenyl]-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1'-biphenyl-4-carboxamide

HRID 131666Notes

Reaction equation

HRID 131666 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20](Cl)=[O:21])=[CH:16][CH:15]=1.[CH3:23][N:24]([CH2:26][C:27]1[CH:28]=[C:29]([CH:31]=[CH:32][C:33]=1[O:34][CH3:35])[NH2:30])[CH3:25]>>[CH3:25][N:24]([CH2:26][C:27]1[CH:28]=[C:29]([NH:30][C:20]([C:17]2[CH:18]=[CH:19][C:14]([C:3]3[CH:4]=[C:5]([C:8]4[O:9][C:10]([CH3:13])=[N:11][N:12]=4)[CH:6]=[CH:7][C:2]=3[CH3:1])=[CH:15][CH:16]=2)=[O:21])[CH:31]=[CH:32][C:33]=1[O:34][CH3:35])[CH3:23]

Participants

3

Reactant 2

HCID 133970963-[(Dimethylamino)methyl]-4-methoxyanilineHCID 210788012'-Methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1'-biphenyl-4-carbonyl chloride

Product 1

HCID 10276091N-[3-(Dimethylaminomethyl)-4-methoxyphenyl]-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1'-biphenyl-4-carboxamide

Procedure

N-[3-(Dimethylaminomethyl)-4-methoxyphenyl]-2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carbonyl chloride and 3-(dimethylaminomethyl)-4-methoxyaniline using method K. LCMS; retention time 2.65 min, MH+ 457.

Sources & evidence

ORD record
ord-a72dfca095be4c3291728f7d44994a9c
Source dataset
uspto-grants-2008_06
Patent number
US07384963B2

Reaction notes

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