HCID 178418361, compound → HCID 178509666, compound

HRID 131687Notes

Reaction equation

HRID 131687 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][NH:10][SH:11](=[O:13])=[O:12])#[N:2].NCC1C=CC=CC=1CNS(=O)=O.[H][H]>[Ni].C(O)C>[NH2:2][CH2:1][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][NH:10][SH:11](=[O:13])=[O:12]

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178509667HCID 178509667, compound

Product 1

HCID 178509666HCID 178509666, compoundYield 181.2%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

N-(2-Aminomethylphenyl)methylsulphonamide N-(2-Cyanophenyl)methylsulphonamide (1.0 g) and raney nickel in ethanol/0.880 ammonia (100 ml, 1:1) were hydrogenated under 64 Atm. of hydrogen at room temperature for 27 h. The reaction was filtered through celite and the solvent evaporated under vacuum to give N-(2-aminomethylphenyl)methylsulphonamide (915 mg, 90%).

Workup

  1. filtrationThe reaction was filtered through celite
  2. customthe solvent evaporated under vacuum

Sources & evidence

ORD record
ord-b0a6b3fbc4084a0b8902d866d55477f7
Source dataset
uspto-grants-2008_06
Patent number
US07384963B2

Reaction notes

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