Iodoethane → HCID 10114213, compound

HRID 131699Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:31]=[CH:30][C:6]([CH2:7][NH:8][C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[C:21]([C:23]4[O:24][C:25]([CH3:28])=[N:26][N:27]=4)[CH:20]=[CH:19][C:18]=3[CH3:29])=[CH:13][CH:12]=2)=[O:10])=[CH:5][CH:4]=1.I[CH2:33][CH3:34]>>[CH2:33]([N:8]([CH2:7][C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:31][CH:30]=1)[C:9]([C:11]1[CH:12]=[CH:13][C:14]([C:17]2[CH:22]=[C:21]([C:23]3[O:24][C:25]([CH3:28])=[N:26][N:27]=3)[CH:20]=[CH:19][C:18]=2[CH3:29])=[CH:15][CH:16]=1)=[O:10])[CH3:34]

Participants

Reactant 2

HCID 6340Iodoethane

HCID 10158653HCID 10158653, compound

Product 1

HCID 10114213HCID 10114213, compound

Procedure

N-Ethyl-N-(4-methoxybenzyl)-2′-methyl-5′-(5-methyl- 1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from N-(4-methoxybenzyl)-2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide and iodoethane using method L. NMR; δH [2H6]—DMSO 7.89,(1H, d), 7.75,(1H, s), 7.55-7.47,(5H, m), 7.30,(1H, m), 6.92,(2H, d), 4.64-4.45,(2H, m), 3.74,(3H, s), 3.34-3.16,(2H, m), 2.55,(3H, s), 2.31,(3H, s), 1.05,(3H, b). LCMS; retention time 3.54 min, MH+ 442.

Sources & evidence

ORD record: ord-0ea25d69044e4bb184cddb53700b4d79
Source dataset: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07384963B2

Reaction notes

Loading…