Iodoethane → HCID 10180774, compound

HRID 131702Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([NH:22][CH2:23][C:24]2[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][CH:25]=2)=[O:21])=[CH:16][CH:15]=1.I[CH2:32][CH3:33]>>[CH2:32]([N:22]([CH2:23][C:24]1[CH:25]=[CH:26][C:27]([CH3:30])=[CH:28][CH:29]=1)[C:20]([C:17]1[CH:18]=[CH:19][C:14]([C:3]2[CH:4]=[C:5]([C:8]3[O:9][C:10]([CH3:13])=[N:11][N:12]=3)[CH:6]=[CH:7][C:2]=2[CH3:1])=[CH:15][CH:16]=1)=[O:21])[CH3:33]

Participants

Reactant 2

HCID 6340Iodoethane

HCID 69218562HCID 69218562, compound

Product 1

HCID 10180774HCID 10180774, compound

Procedure

N-Ethyl-2′-methyl-N-(4-methylbenzyl)-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-N-(4-methylbenzyl)-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide and iodoethane using method L. NMR; δH [2H6]—DMSO 7.88,(1H, d), 7.76,(1H, s), 7.56-7.45,(5H, m), 7.25-7.13,(4H,m), 4.66-4.48,(2H, m), 3.37-3.18,(2H, m), 2.55,(3H, s), 2.31-2.28,(6H, m), 1.05,(3H, b). LCMS; retention time 3.70 min, MH+ 426.

Sources & evidence

ORD record: ord-2d0521f7d10d4111b9092e7b5b18815c
Source dataset: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07384963B2

Reaction notes

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