4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoic Acid → HCID 10118153, compound

HRID 131706Notes

Reaction equation

HRID 131706 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20](O)=[O:21])=[CH:16][CH:15]=1.[NH2:23][CH2:24][CH2:25][C:26]1[CH:27]=[CH:28][C:29]([O:36][CH3:37])=[C:30]([S:32]([NH2:35])(=[O:34])=[O:33])[CH:31]=1>>[CH3:37][O:36][C:29]1[CH:28]=[CH:27][C:26]([CH2:25][CH2:24][NH:23][C:20]([C:17]2[CH:16]=[CH:15][C:14]([C:3]3[CH:4]=[C:5]([C:8]4[O:9][C:10]([CH3:13])=[N:11][N:12]=4)[CH:6]=[CH:7][C:2]=3[CH3:1])=[CH:19][CH:18]=2)=[O:21])=[CH:31][C:30]=1[S:32](=[O:34])(=[O:33])[NH2:35]

Participants

3

Reactant 2

HCID 112201194-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoic AcidHCID 15034418HCID 15034418, compound

Product 1

HCID 10118153HCID 10118153, compound

Procedure

N-[2-(4-Methoxy-3-sulphamoylphenyl)ethyl]-2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylic acid and 5-(2-aminoethyl)-2-methoxybenzene-sulphonamide using method M. NMR; δH [2H6]—DMSO 8.66,(1H, t), 7.93-7.88,(3H, m), 7.76,(1H, d), 7.64,(1H, d), 7.54,(1H, d), 7.50,(2H, d), 7.45,(1H, dd), 7.14,(1H, d), 7.02,(2H, b), 3.86,(3H, s), 3.48,(2H, q), 2.85,(2H, t), 2.56,(3H, s), 2.31,(3H, s). LCMS; retention time 2.99 min, MH+ 507.

Sources & evidence

ORD record
ord-e9e4deb9b439484fb5b91e843b8e2a2a
Source dataset
uspto-grants-2008_06
Patent number
US07384963B2

Reaction notes

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