2-(Trifluoromethyl)benzylamine → HCID 10114893, compound

HRID 131707Notes

Reaction equation

HRID 131707 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([OH:22])=O)=[CH:16][CH:15]=1.[F:23][C:24]([F:34])([F:33])[C:25]1[CH:32]=[CH:31][CH:30]=[CH:29][C:26]=1[CH2:27][NH2:28]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:15]=[CH:16][C:17]([C:20]([NH:28][CH2:27][C:26]2[CH:29]=[CH:30][CH:31]=[CH:32][C:25]=2[C:24]([F:23])([F:33])[F:34])=[O:22])=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 764472-(Trifluoromethyl)benzylamineHCID 112201194-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoic Acid

Product 1

HCID 10114893HCID 10114893, compound

Procedure

2′-Methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-trifluoromethylbenzyl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylic acid and 2-trifluoromethylbenzylamine using method N. NMR; δH [2H6]—DMSO 9.23,(1H, t), 8.04,(2H, d), 7.91,(1H, dd), 7.78,(1H, d), 7.75,(1H, d), 7.67,(1H, t), 7.56,(4H, m), 7.49,(1H, t), 4.70,(2H, d), 2.57,(3H, s),2.33,(3H, s). LCMS; retention time 3.58 min, MH+ 452.

Sources & evidence

ORD record
ord-3bd0a7a561894adb922ce4bac7e4ee42
Source dataset
uspto-grants-2008_06
Patent number
US07384963B2

Reaction notes

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