3-(Trifluoromethyl)benzylamine → HCID 10275729, compound

HRID 131708Notes

Reaction equation

HRID 131708 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20](O)=[O:21])=[CH:16][CH:15]=1.[F:23][C:24]([F:34])([F:33])[C:25]1[CH:26]=[C:27]([CH:30]=[CH:31][CH:32]=1)[CH2:28][NH2:29]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([NH:29][CH2:28][C:27]2[CH:30]=[CH:31][CH:32]=[C:25]([C:24]([F:23])([F:33])[F:34])[CH:26]=2)=[O:21])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 759623-(Trifluoromethyl)benzylamineHCID 112201194-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoic Acid

Product 1

HCID 10275729HCID 10275729, compound

Procedure

2′-Methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(3-trifluoromethylbenzyl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylic acid and 3-trifluoromethylbenzylamine using method N. NMR; δH [2H6]—DMSO 9.24,(1H, t), 8.00,(2H, d), 7.90,(1H, dd), 7.77,(1H, d), 7.69-7.52,(7H, m), 4.59,(2H, d), 2.56,(3H, s), 2.31,(3H, s). LCMS; retention time 3.59 min, MH+ 452.

Sources & evidence

ORD record
ord-8c3b322e85d840f78afcae8dd9fc2379
Source dataset
uspto-grants-2008_06
Patent number
US07384963B2

Reaction notes

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