3-Methylbenzylamine → HCID 10294228, compound

HRID 131712Notes

Reaction equation

HRID 131712 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20](O)=[O:21])=[CH:16][CH:15]=1.[CH3:23][C:24]1[CH:25]=[C:26]([CH:29]=[CH:30][CH:31]=1)[CH2:27][NH2:28]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([NH:28][CH2:27][C:26]2[CH:29]=[CH:30][CH:31]=[C:24]([CH3:23])[CH:25]=2)=[O:21])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 660153-MethylbenzylamineHCID 112201194-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoic Acid

Product 1

HCID 10294228HCID 10294228, compound

Procedure

2′-Methyl-N-(3-methylbenzyl)-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylic acid and 3-methylbenzylamine using method N. NMR; δH [2H6]—DMSO 9.11,(1H, t), 8.00,(2H, d), 7.90,(1H, dd), 7.77,(1H, d), 7.56-7.51,(3H, m), 7.21,(1H, t), 7.14-7.11,(2H, m), 7.05,(1H, d), 4.47,(2H, d), 2.56,(3H, s), 2.31, (3H, s), 2.29,(3H, s). LCMS; retention time 3.48 min, MH+ 398.

Sources & evidence

ORD record
ord-632f8d6d7be445d7b95e99b6913ade8c
Source dataset
uspto-grants-2008_06
Patent number
US07384963B2

Reaction notes

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