Methyl iodide → HCID 10112301, compound

HRID 131731Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([NH:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([CH3:30])[CH:25]=2)=[O:21])=[CH:16][CH:15]=1.I[CH3:32]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:15]=[CH:16][C:17]([C:20]([N:22]([CH3:32])[CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([CH3:30])[CH:25]=2)=[O:21])=[CH:18][CH:19]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 10294228HCID 10294228, compound

Product 1

HCID 10112301HCID 10112301, compound

Procedure

2′-Methyl-N-methyl-N-(3-methylbenzyl)-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-N-(3-methylbenzyl)-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide and iodomethane using method L. NMR; δH [2H6]—DMSO 7.89,(1H, d), 7.76,(1H, s), 7.55-7.48,(5H, m), 7.27,(1H, t), 7.16-7.10,(2H, m), 7.00,(1H, b), 4.66-4.50,(2H, m), 2.89,(3H, m), 2.55,(3H, s), 2.32,(3H, s). LCMS; retention time 3.52 min, MH+ 412.

Sources & evidence

ORD record: ord-5a00cafabf284593a7a2d0b888735631
Source dataset: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07384963B2

Reaction notes

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