Methyl iodide → 2'-Methyl-N-methyl-N-(2-methylbenzyl)-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1'-biphenyl-4-carboxamide

HRID 131732Notes

Reaction equation

HRID 131732 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([NH:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[CH3:30])=[O:21])=[CH:16][CH:15]=1.I[CH3:32]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([N:22]([CH3:32])[CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[CH3:30])=[O:21])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 102224432'-Methyl-N-(2-methylbenzyl)-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1'-biphenyl-4-carboxamide

Product 1

HCID 102951012'-Methyl-N-methyl-N-(2-methylbenzyl)-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1'-biphenyl-4-carboxamide

Procedure

2′-Methyl-N-methyl-N-(2-methylbenzyl)-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-N-(2-methylbenzyl)-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide and iodomethane using method L. NMR; δH [2H6]—DMSO 7.89,(1H, m), 7.77,(1H, m), 7.59-7.43,(5H, m), 7.22,(4H, m), 4.71-4.53,(2H, m), 2.93-2.87,(3H, m), 2.55,(3H, s), 2.32-2.29,(3H, m). LCMS; retention time 3.48 min, MH+ 412.

Sources & evidence

ORD record
ord-ae2074fb0b4849c7bfcab9c20b44358f
Source dataset
uspto-grants-2008_06
Patent number
US07384963B2

Reaction notes

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