Hydrochloric Acid → Salcaprozate sodium

HRID 131762Notes

Reaction equation

HRID 131762 reaction equation
[Na].[CH:2]1[CH:3]=[CH:4][C:5]([OH:21])=[C:6]([C:8]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O-:20])=[O:19])=[O:9])[CH:7]=1.[Na+:22].Cl>O>[CH:2]1[CH:3]=[CH:4][C:5]([OH:21])=[C:6]([C:8]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O-:20])=[O:19])=[O:9])[CH:7]=1.[Na+:22]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86585230HCID 86585230, compound

Product 1

HCID 23669833Salcaprozate sodium

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Free acid of SNAC (i.e. N-(8-[2-hydroxybenzoyl]amino)caprylic acid) was prepared as follows. The monosodium SNAC prepared in Example 12 was acidified with 1 equivalent of concentrated hydrochloric acid in water and stirred. The solution was then vacuum filtered and vacuum dried to yield the free acid.

Workup

  1. filtrationvacuum filtered
  2. customvacuum dried
  3. customto yield the free acid

Sources & evidence

ORD record
ord-e3fb7a5ab82e47f88e7f1700172845f2
Source dataset
uspto-grants-2008_06
Patent number
US07384982B2

Reaction notes

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