HRID131822

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2155

2-Aminothiazole

C3H4N2S

HCID67767

2,5-Difluoronitrobenzene

C6H3F2NO2

HCID78828

2,3-Dimethoxyphenol

C8H10O3

HCID66998831

未命名化合物

2 次

PRODUCTS

生成物

结构：COc1cccc(Oc2ccc(F)cc2NC(=O)Nc2nccs2)c1OC

HCID59733076

未命名化合物

收率 65%

结构：COc1cccc(Oc2ccc(F)cc2[N+](=O)[O-])c1OC

HCID66999058

未命名化合物

收率 68%

PROCEDURE

实验过程

2-(2,3-Dimethoxyphenoxy)-5-fluoro-1-nitrobenzene (1.0 g, 68%) was prepared from 2,3-dimethoxyphenol (0.85 g, 5.5 mmol) and 2,5-difluoro-1-nitrobenzene (0.80 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2,3-dimethoxyphenoxy)-5-fluoroaniline (0.67 g, 75%) following general procedure C. N-[2-(2,3-Dimethoxyphenoxy)-5-fluorophenyl]-N′-(thiazol-2-yl)urea (126 g, 65%) was prepared from 2-(2,3-dimethoxyphenoxy)-5-fluoroaniline (132 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3a036b54790f49d2a1b634cd9fd7ccaa
来源数据集: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07384967B2
来源说明: uspto-grants-2008_06

反应 SMILES

[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[CH:7][CH:6]=[CH:5][C:4]=1[OH:11].F[C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=1[N+:20]([O-:22])=[O:21].[CH3:23][O:24][C:25]1[C:39]([O:40][CH3:41])=[CH:38][CH:37]=[CH:36][C:26]=1[O:27][C:28]1[CH:34]=[CH:33][C:32]([F:35])=[CH:31][C:29]=1[NH2:30].[NH2:42][C:43]1[S:44][CH:45]=[CH:46][N:47]=1>>[CH3:1][O:2][C:3]1[C:8]([O:9][CH3:10])=[CH:7][CH:6]=[CH:5][C:4]=1[O:11][C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=1[N+:20]([O-:22])=[O:21].[CH3:23][O:24][C:25]1[C:39]([O:40][CH3:41])=[CH:38][CH:37]=[CH:36][C:26]=1[O:27][C:28]1[CH:34]=[CH:33][C:32]([F:35])=[CH:31][C:29]=1[NH:30][C:4]([NH:42][C:43]1[S:44][CH:45]=[CH:46][N:47]=1)=[O:11]