HCID 59732760, compound → HCID 59732857, compound

HRID 131881Notes

Reaction equation

HRID 131881 reaction equation
C[O:2][C:3](=[O:37])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][C:14]2[N:15]=[C:16]([NH:19][C:20]([NH:22][C:23]3[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][C:24]=3[C:30]([CH:32]3[CH2:36][CH2:35][CH2:34][CH2:33]3)=[O:31])=[O:21])[S:17][CH:18]=2)=[CH:7][CH:6]=1>[Li+].[OH-]>[CH:32]1([C:30]([C:24]2[CH:25]=[C:26]([CH3:29])[CH:27]=[CH:28][C:23]=2[NH:22][C:20](=[O:21])[NH:19][C:16]2[S:17][CH:18]=[C:14]([CH2:13][CH2:12][O:11][C:8]3[CH:7]=[CH:6][C:5]([CH2:4][C:3]([OH:37])=[O:2])=[CH:10][CH:9]=3)[N:15]=2)=[O:31])[CH2:36][CH2:35][CH2:34][CH2:33]1

Participants

3

Reactant 1

HCID 59732760HCID 59732760, compound

Product 1

HCID 59732857HCID 59732857, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 3939Lithium HydroxideSolvent

Procedure

[4-(2-{2-[3-(2-Cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl}ethoxy)-phenyl]acetic acid (25 mg, 86%) was prepared from [4-(2-{2-[3-(2-Cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl)ethoxy)-phenyl]acetic acid methyl ester (0.03 g, 0.06 mmol) and 2.5M LiOH (20 uL) following the general procedure J.

Sources & evidence

ORD record
ord-73a5ed426c6f47dba932400196be1ca7
Source dataset
uspto-grants-2008_06
Patent number
US07384967B2

Reaction notes

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