Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1319008Notes

Reaction equation

HRID 1319008 reaction equation
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>C1CCC(P(C2CCCCC2)[c]23->[Fe+2]456789%10(<-[cH]([cH]->4[cH-]->52)[cH]->63)<-[cH]2[cH]->7[cH-]->8[c]->9(P(C3C4CC5CC(C4)CC3C5)C3C4CC5CC(C4)CC3C5)[cH]->%102)CC1.CC(=O)[O-].CS(C)=O.[Cl][Cu].[Cs+]>FC(F)(F)c1ccc(N2CCOCC2)cc1

Participants

9

Reactant 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

Product 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholineYield 0%HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholineYield 0%

Reagents, catalysts & solvents 4

HCID 5152919Cesium acetateReagentHCID 62652Cuprous chlorideCatalystHCID 178420529HCID 178420529, compoundCatalystHCID 679Dimethyl SulfoxideSolvent5×

Conditions

Temperature
60 °C

Workup

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · Keep liquid
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

Sources & evidence

ORD record
ord-140326fbe1fe410f8d3e60af342bf739
Source dataset
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
Original link
View source

Reaction notes

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