2-(carbamoylamino)-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]acetamide → HCID 44595798, compound

HRID 13191Notes

Reaction equation

HRID 13191 reaction equation
[C:1]([NH:4][CH2:5][C:6]([NH:8][C@@H:9]([CH3:36])[C@H:10]([O:19][C:20]1[CH:21]=[C:22]2[C:26](=[CH:27][CH:28]=1)[N:25]([C:29]1[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=1)[N:24]=[CH:23]2)[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=1)=[O:7])(=[O:3])N>C(O)(=O)C>[F:35][C:32]1[CH:33]=[CH:34][C:29]([N:25]2[C:26]3[C:22](=[CH:21][C:20]([O:19][C@H:10]([C:11]4[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=4)[C@@H:9]([N:8]4[C:6](=[O:7])[CH2:5][NH:4][C:1]4=[O:3])[CH3:36])=[CH:28][CH:27]=3)[CH:23]=[N:24]2)=[CH:30][CH:31]=1

Participants

3

Reactant 1

HCID 593396582-(carbamoylamino)-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]acetamide

Product 1

HCID 44595798HCID 44595798, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
120 °C

Procedure

2-(carbamoylamino)-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]acetamide (270, 141 mg, 0.29 mmol) was dissolved in acetic acid (3 mL). The reaction was heated at 120° C. with stirring for 20 h. The HOAc was evaporated and the product was purified by preparative HPLC.

Workup

  1. customThe HOAc was evaporated
  2. customthe product was purified by preparative HPLC

Sources & evidence

ORD record
ord-736b3f03b3274a69b94fabb49b195670
Source dataset
uspto-grants-2010_06
Patent number
US07728030B2

Reaction notes

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