2-Aminothiazole → HCID 59733091, compound

HRID 131931Notes

Reaction equation

HRID 131931 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)=[O:10].NC1C=C(F)C=CC=1[C:19](O)=[O:20].[NH2:27][C:28]1[S:29][CH:30]=[CH:31][N:32]=1>>[F:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]([C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)=[O:10])=[C:2]([NH:1][C:19]([NH:27][C:28]2[S:29][CH:30]=[CH:31][N:32]=2)=[O:20])[CH:7]=1

Participants

4

Reactant 3

HCID 21552-AminothiazoleHCID 27249674-Fluoroanthranilic acidHCID 12750535HCID 12750535, compound2×

Product 1

HCID 59733091HCID 59733091, compoundYield 65%

Procedure

(2-Amino-4-fluoro-phenyl)-thiophen-2-yl-methanone was (618 g, 28%) was prepared from 2-amino-4-fluoro-benzoic acid (1.55 g, 10 mmol) following the general procedure S. N-[5-Fluoro-2-(thiophene-2-carbonyl)-phenyl]-N′-(thiazol-2-yl)urea (113 mg, 65%) was prepared from (2-amino-4-fluoro-phenyl)-thiophen-2-yl-methanone (110 mg, 0.5 mmol) and 2-aminothiazole (0.060 g, 0.6 mmol) following the general procedure D.

Sources & evidence

ORD record
ord-eef39b9650254716a25e21a3e198bbff
Source dataset
uspto-grants-2008_06
Patent number
US07384967B2

Reaction notes

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