2-Aminothiazole → HCID 66999080, compound

HRID 131968Notes

Reaction equation

HRID 131968 reaction equation
[CH:1]1([NH2:6])CCC[CH2:2]1.FC1C=C(C)C=CC=1[N+]([O-])=[O:15].[CH:18]1([NH:23][C:24]2[CH:30]=[C:29]([CH3:31])[CH:28]=[CH:27][C:25]=2[NH2:26])[CH2:22][CH2:21][CH2:20][CH2:19]1.N[C:33]1[S:34]C=[CH:36][N:37]=1>>[CH:18]1([NH:23][C:24]2[CH:30]=[C:29]([CH3:31])[CH:28]=[CH:27][C:25]=2[NH2:26])[CH2:22][CH2:21][CH2:20][CH2:19]1.[CH:18]1([NH:23][C:24]2[CH:30]=[C:29]([CH3:31])[CH:28]=[CH:27][C:25]=2[NH:26][C:36]([NH:37][C:33]2[S:34][CH:2]=[CH:1][N:6]=2)=[O:15])[CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

6

Reactant 4

HCID 21552-AminothiazoleHCID 2906CyclopentylamineHCID 67966Benzene, 2-fluoro-4-methyl-1-nitro-HCID 66999080HCID 66999080, compound

Product 2

HCID 59733020HCID 59733020, compoundYield 62%HCID 66999080HCID 66999080, compoundYield 68%

Procedure

2-Cyclopentylamino-4-methyl-aniline (0.64 g, 68%) was prepared from cyclopentylamine (1.0 ml, 10.0 mmol) and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure W. 1-(2-Cyclopentylamino-4-methyl-phenyl)-3-thiazol-2-yl-urea (195 mg, 62%) was prepared from 2-cyclopentylamino-4-methyl-aniline (190 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.

Sources & evidence

ORD record
ord-b5ba369bef784784ad709e90c534c2a8
Source dataset
uspto-grants-2008_06
Patent number
US07384967B2

Reaction notes

Loading…