HRID131973

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2155

2-Aminothiazole

C3H4N2S

HCID598129

4-Fluoro-3-nitrobenzaldehyde

C7H4FNO3

HCID2737367

2-Fluoro-6-methoxyphenol

C7H7FO2

HCID86593084

未命名化合物

2 次

PRODUCTS

生成物

结构：COc1cccc(F)c1Oc1ccc(C=O)cc1NC(=O)Nc1nccs1

HCID59732954

未命名化合物

收率 69%

结构：COc1cccc(F)c1Oc1ccc(C=O)cc1[N+](=O)[O-]

HCID86593083

未命名化合物

收率 70%

PROCEDURE

实验过程

4-(2-Fluoro-6-methoxy-phenoxy)-3-nitrobenzaldehyde (1.0 g, 70%) was prepared from 2-fluoro-6-methoxyphenol (0.78 g, 5.5 mmol) and 4-fluoro-3-nitrobenzaldehyde (0.84 g, 5.0 mmol) following the general procedure A. This was reduced to 5-formyl-2-(2-fluoro-6-methoxy-phenoxy)-aniline (0.57 g, 62%) following general procedure B. 1-[2-(2-Fluoro-6-methoxy-phenoxy)-5-formyl-phenyl]-3-thiazol-2-yl-urea (265 mg, 69%) was prepared from 5-formyl-2-(2-fluoro-6-methoxy-phenoxy)-aniline (261 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-971efa14457b47c499e8f06cd1911d93
来源数据集: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07384967B2
来源说明: uspto-grants-2008_06

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[OH:10].F[C:12]1[CH:19]=[CH:18][C:15]([CH:16]=[O:17])=[CH:14][C:13]=1[N+:20]([O-:22])=[O:21].[CH:23]([C:25]1[CH:26]=[CH:27][C:28]([O:32][C:33]2[C:38]([O:39][CH3:40])=[CH:37][CH:36]=[CH:35][C:34]=2[F:41])=[C:29]([CH:31]=1)[NH2:30])=[O:24].[NH2:42][C:43]1[S:44][CH:45]=[CH:46][N:47]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[O:10][C:12]1[CH:19]=[CH:18][C:15]([CH:16]=[O:17])=[CH:14][C:13]=1[N+:20]([O-:22])=[O:21].[F:41][C:34]1[CH:35]=[CH:36][CH:37]=[C:38]([O:39][CH3:40])[C:33]=1[O:32][C:28]1[CH:27]=[CH:26][C:25]([CH:23]=[O:24])=[CH:31][C:29]=1[NH:30][C:3]([NH:42][C:43]1[S:44][CH:45]=[CH:46][N:47]=1)=[O:10]