HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Sodium Bicarbonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Amino-4-(propane-1-sulfonyl)thiophene-2-carboxylic acid | HCID 4350089 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Sodium Bicarbonate | HCID 516892 | — |
| Product | 3-Amino-4-(propane-1-sulfonyl)thiophene-2-carboxylic acid | HCID 4350089 | — |
Reaction Steps
Coupling of ligand to NHS-activated thiopropionic acid Sepharose: 3-amino-4(propylsulfonyl)thiophene-2-carboxylic acid was prepared as described in WO 02/05959 (ligand 12). A soluble mixture of a solution of 565 mg of 3-amino-4(propylsulfonyl)thiophene-2-carboxylic acid (2.27 mmol) in 2 ml of dist. water, 2 ml of 1M NaHCO3 and 2 ml of ethanol was prepared and adjusted to pH 8.5 with careful addition of 50% aqueous NaOH.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07385040B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-9504fd45ea8140eca8c17453d98afe08 |
| Source note | uspto-grants-2008_06 |