Water → Sodium Bicarbonate

HRID 131986Notes

Reaction equation

HRID 131986 reaction equation
[NH2:1][C:2]1[C:6]([S:7]([CH2:10][CH2:11][CH3:12])(=[O:9])=[O:8])=[CH:5][S:4][C:3]=1[C:13]([OH:15])=[O:14].[OH2:16].[OH-].[Na+:18]>C(O)C>[NH2:1][C:2]1[C:6]([S:7]([CH2:10][CH2:11][CH3:12])(=[O:9])=[O:8])=[CH:5][S:4][C:3]=1[C:13]([OH:15])=[O:14].[C:13]([O-:15])([OH:16])=[O:14].[Na+:18]

Participants

6

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 43500893-Amino-4-(propane-1-sulfonyl)thiophene-2-carboxylic acid

Product 2

HCID 516892Sodium BicarbonateHCID 43500893-Amino-4-(propane-1-sulfonyl)thiophene-2-carboxylic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Coupling of ligand to NHS-activated thiopropionic acid Sepharose: 3-amino-4(propylsulfonyl)thiophene-2-carboxylic acid was prepared as described in WO 02/05959 (ligand 12). A soluble mixture of a solution of 565 mg of 3-amino-4(propylsulfonyl)thiophene-2-carboxylic acid (2.27 mmol) in 2 ml of dist. water, 2 ml of 1M NaHCO3 and 2 ml of ethanol was prepared and adjusted to pH 8.5 with careful addition of 50% aqueous NaOH.

Sources & evidence

ORD record
ord-9504fd45ea8140eca8c17453d98afe08
Source dataset
uspto-grants-2008_06
Patent number
US07385040B2

Reaction notes

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