Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1320568노트

반응식

HRID 1320568 반응식
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CC(C)(C)[O-].[K+].CS(C)=O.CS(C)=O.CS(C)=O.CS(C)=O.CS(C)=O.Cc1cccc(C)c1.Cc1cccc(C)c1.Cc1cccc(C)c1.Cc1cccc(C)c1.Cc1cccc(C)c1>Cn1c(=O)c2c(ncn2C)n(C)c1=O.FC(F)(F)c1ccc(N2CCOCC2)cc1.FC(F)(F)c1cccc(N2CCOCC2)c1

참가 물질

9

반응물 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

생성물 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholine수율 5.6%HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholine수율 0%

시약·촉매·용매 4

HCID 23665647Potassium tert-butoxide시약HCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)촉매HCID 679Dimethyl Sulfoxide용매5회HCID 7929M-Xylene용매5회

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온도
60 °C

후처리

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 상 유지
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

출처 및 근거

ORD 기록
ord-b9cf6ac93905486da80207ae496239b0
출처 데이터셋
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
원본 링크
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