tert-Butoxy bis(dimethylamino)methane → HCID 59733753, compound

HRID 132113Notes

Reaction equation

[C:1]([C:5]1[CH:6]=[C:7]([C:11]2([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[CH2:16][CH2:15][C:14](=[O:17])[CH2:13][CH2:12]2)[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].C(O[CH:31](N(C)C)[N:32]([CH3:34])[CH3:33])(C)(C)C>C1(C)C=CC=CC=1>[C:1]([C:5]1[CH:6]=[C:7]([C:11]2([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[CH2:16][CH2:15][C:14](=[O:17])/[C:13](=[CH:31]/[N:32]([CH3:34])[CH3:33])/[CH2:12]2)[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

Conditions

Temperature: 85 °C

Procedure

To a stirred solution of tert-butyl 1-(3-tert-butylphenyl)-4-oxocyclohexylcarbamate (691 mg, 2.0 mmol) in Toluene (5 mL) was added tert-butoxybis(dimethylamino)methane (454 μL, 2.2 mmol). The reaction was stirred at 85° C. overnight. The reaction was concentrated and used crude in the next step.

Workup

concentrationThe reaction was concentrated

Sources & evidence

ORD record: ord-c031964a759547a3b6ff31357bdf101f
Source dataset: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07385085B2

Reaction notes

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