反应详情

Benzyl (2S,3S)-4-(2,4-difluorophenoxy)-3-hydroxybutan-2-ylcarbamate (426 mg, 1.21 mmol) in ethanol (20 mL) was hydrogenated over Pd (10% on carbon) (40.0 mg) at r.t. and atmospheric pressure overnight. The mixture was filtered through celite, evaporated, dissolved in ethanol and filtered through a syringe filter. On evaporation a white solid was obtained. This was dissolved in ethanol (4 mL) and diethyl ether (6 mL) and 1M HCl in diethyl ether was added (1.5 mL) under stirring. Evaporation, coevaporation from dichloromethane/diethylether gave the title compound as a solid, (290 mg, 94%).

1. customatmospheric pressure overnight
2. filtrationThe mixture was filtered through celite
3. customevaporated
4. dissolutiondissolved in ethanol
5. filtrationfiltered through a syringe
6. filtrationfilter
7. customOn evaporation a white solid
8. customwas obtained
9. customEvaporation, coevaporation from dichloromethane/diethylether