反应详情

Trifluoroacetic acid (3 mL) was added to a solution of tert-Butyl 4-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)piperidine-1-carboxylate (260 mg, 0.79 mmol) in dichloromethane (3 mL). Reaction stirred at room temperature for 1 hour. Reaction mixture was concentrated in vacuo. Residue was dissolved in methanol. Dowex 1×4-200 ion exchange resin was added to the mixture to create a slurry. Mixture stirred at room temperature for 30 minutes. Resin was filtered off and washed with methanol. Filtrate was concentrated. Title compound was obtained as dark foam in quantitative yield. MS m/e (M+H)+=231.1.

1. customReaction
2. customReaction mixture
3. concentrationwas concentrated in vacuo
4. dissolutionResidue was dissolved in methanol
5. additionDowex 1×4-200 ion exchange resin was added to the mixture
6. stirringMixture stirred at room temperature for 30 minutes
7. filtrationResin was filtered off
8. washwashed with methanol
9. concentrationFiltrate was concentrated