Hydrochloric Acid → HCID 67319103, compound

HRID 132213Notes

Reaction equation

HRID 132213 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]2[C:19](=[O:20])[C:18]3[CH:21]=[CH:22][CH:23]=[CH:24][C:17]=3[NH:16][S:15]2(=[O:26])=[O:25])[CH2:10][CH2:9]1)=O)(C)(C)C.O1CCOCC1.[ClH:33]>>[ClH:33].[O:26]=[S:15]1(=[O:25])[CH:14]([CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[C:19](=[O:20])[C:18]2[CH:21]=[CH:22][CH:23]=[CH:24][C:17]=2[NH:16]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59731969HCID 59731969, compound

Product 1

HCID 67319103HCID 67319103, compound

Procedure

4-(2,2,4-Trioxo-1,2,3,4-tetrahydro-2,1-benzothiazin-3-yl)-piperidine-1-carboxylic acid tert-butyl ester (175 mg, 0.46 mmol) was dissolved in 4M hydrogen chloride in 1,4-dioxane (3.0 mL, 12.0 mmol). Reaction stirred at room temperature for 45 minutes. Reaction mixture was concentrated to dryness in vacuo. Title compound was obtained as pink solid in quantitative yield. MS m/e (M+H)+=281.1.

Workup

  1. customReaction
  2. customReaction mixture
  3. concentrationwas concentrated to dryness in vacuo

Sources & evidence

ORD record
ord-bd651c3ad3144774830734249c9b86cf
Source dataset
uspto-grants-2008_06
Patent number
US07384930B2

Reaction notes

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