Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1322580Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1322580
C1COCCN1.FC(F)(F)c1ccc(I)cc1>CC(C)(C)[O-].CC(C)c1cccc(C(C)C)c1N1C=[N+](c2c(C(C)C)cccc2C(C)C)CC1.CS(C)=O.[Cl-].[Cu][O][Cu].[Na+]>FC(F)(F)c1ccc(N2CCOCC2)cc1

Komponenten

9

Edukt 2

HCID 8083MorpholineHCID 67993Benzene, 1-iodo-4-(trifluoromethyl)-

Produkt 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholineAusbeute 3,74 %HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholineAusbeute 0 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 23676156Sodium t-butoxideReagenzHCID 27349181,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chlorideKatalysatorHCID 178505380HCID 178505380, VerbindungKatalysatorHCID 679Dimethyl SulfoxideLösungsmittel5×

Reaktionsbedingungen

Temperatur
80 °C

Aufarbeitung

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid-Phase beibehalten
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

Quellen und Nachweise

ORD-Eintrag
ord-aa90d4b4e9b9450c94ca7e70fe10b891
Quelldatensatz
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
Originallink
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