Trifluoroacetic acid → HCID 68825958, compound

HRID 132272Notes

Reaction equation

HRID 132272 reaction equation
[NH2:1][C:2]1[C:3]([CH3:41])=[CH:4][C:5]2[CH2:11][C@@H:10]([NH:12][C:13]([N:15]3[CH2:20][CH2:19][CH:18]([N:21]4[CH2:30][C:29]5[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=5)[NH:23][C:22]4=[O:31])[CH2:17][CH2:16]3)=[O:14])[C:9](=[O:32])[N:8]([CH2:33][C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[CH2:7][C:6]=2[CH:40]=1.[F:42][C:43]([F:48])([F:47])[C:44]([OH:46])=[O:45]>ClCCl>[F:42][C:43]([F:48])([F:47])[C:44]([OH:46])=[O:45].[NH2:1][C:2]1[C:3]([CH3:41])=[CH:4][C:5]2[CH2:11][C@@H:10]([NH:12][C:13]([N:15]3[CH2:16][CH2:17][CH:18]([N:21]4[CH2:30][C:29]5[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=5)[NH:23][C:22]4=[O:31])[CH2:19][CH2:20]3)=[O:14])[C:9](=[O:32])[N:8]([CH2:33][C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[CH2:7][C:6]=2[CH:40]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59732025HCID 59732025, compound

Product 1

HCID 68825958HCID 68825958, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(R)-N-(8-Amino-2-benzyl-7-methyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl)-4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)piperidine-1-carboxamide (95 mg, 0.15 mmol) was dissolved in dichloromethane (2 mL). Trifluoroacetic acid (1 mL) was added to the mixture. Reaction stirred at room temperature for 1 hour. Mixture was concentrated in vacuo. Residue was purified by preparatory HPLC. Solvent was lyophilized from the proper fractions. Title compound was obtained as white solid in 64% yield. MS m/e (M+H)+=553.

Workup

  1. customReaction
  2. concentrationMixture was concentrated in vacuo
  3. customResidue was purified by preparatory HPLC

Sources & evidence

ORD record
ord-02af3a9141a842bcb5ba326fbf0bb745
Source dataset
uspto-grants-2008_06
Patent number
US07384930B2

Reaction notes

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