反应详情

tert-Butyl 4-(3-phenylisoxazol-5-yl)piperidine-1-carboxylate (225 mg, 0.78 mmol) was diluted in dichloromethane (3 mL). Trifluoroacetic acid (3 mL) was added to the mixture. Reaction stirred at room temperature for 1 hour. Mixture was diluted with dichloromethane and then concentrated in vacuo. Residue was treated with aqueous sodium bicarbonate. Mixture was extracted 2× ethyl acetate. Combined extracts were washed 1× water, 1× brine. Organic layer was dried (magnesium sulfate), filtered and concentrated in vacuo. Title compound was obtained as white solid in 76% yield. MS m/e (M+H)+=229.1.

1. customReaction
2. concentrationconcentrated in vacuo
3. additionResidue was treated with aqueous sodium bicarbonate
4. extractionMixture was extracted 2× ethyl acetate
5. washCombined extracts were washed 1× water, 1× brine
6. dry with materialOrganic layer was dried (magnesium sulfate)
7. filtrationfiltered
8. concentrationconcentrated in vacuo