Hydrochloric Acid → HCID 67363486, compound

HRID 132351Notes

Reaction equation

HRID 132351 reaction equation
[O:1]=[C:2]1[NH:7][C:6]2[N:8]=[CH:9][CH:10]=[CH:11][C:5]=2[CH2:4][N:3]1[CH:12]1[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]1.[ClH:25]>O1CCOCC1>[ClH:25].[ClH:25].[NH:15]1[CH2:14][CH2:13][CH:12]([N:3]2[CH2:4][C:5]3[CH:11]=[CH:10][CH:9]=[N:8][C:6]=3[NH:7][C:2]2=[O:1])[CH2:17][CH2:16]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59731886HCID 59731886, compound

Product 1

HCID 67363486HCID 67363486, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A suspension of tert-butyl 4-(2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-3(4H)-yl)piperidine-1-carboxylate (220 mg, 0.66 mmol) in 4N hydrogen chloride in 1,4-dioxane (5.0 mL) was stirred at room temperature for 45 minutes. Mixture was concentrated in vacuo. Crystallization from ethanol and ethyl acetate afforded the title compound as white solid in 62% yield. (M+H)+=233.2.

Workup

  1. concentrationMixture was concentrated in vacuo
  2. customCrystallization from ethanol and ethyl acetate

Sources & evidence

ORD record
ord-cebe92b9bf6b438da997d253c5900c3f
Source dataset
uspto-grants-2008_06
Patent number
US07384931B2

Reaction notes

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