Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1324005Notes

Reaction equation

HRID 1324005 reaction equation
C1COCCN1.FC(F)(F)c1ccc(I)cc1>COc1cc(C(c2ccccc2)c2ccccc2)c(N2C=CN(c3c(C(c4ccccc4)c4ccccc4)cc(OC)cc3C(c3ccccc3)c3ccccc3)C2)c(C(c2ccccc2)c2ccccc2)c1.CS(C)=O.O=C([O-])[O-].[Cs+].[Cu][I]>FC(F)(F)c1ccc(N2CCOCC2)cc1

Participants

9

Reactant 2

HCID 8083MorpholineHCID 67993Benzene, 1-iodo-4-(trifluoromethyl)-

Product 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholineYield 0%HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholineYield 0%

Reagents, catalysts & solvents 4

HCID 14794698CID 14794698ReagentHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)CatalystHCID 102190031HCID 102190031, compoundCatalystHCID 679Dimethyl SulfoxideSolvent5×

Conditions

Temperature
30 °C

Workup

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · Keep liquid
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

Sources & evidence

ORD record
ord-8d109c98d9944a6a975e284a7d517cd1
Source dataset
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
Original link
View source

Reaction notes

Loading…