反应详情

(R)-3-(7-chloro-4-(hydroxymethyl)-1H-indazol-5-yl)-1-methoxy-1-oxopropan-2-yl benzoate (6.5 g, 16.72 mmol) in dichloromethane (100.0 ml, 1554 mmol) was added Diisopropylethyl amine (2.59 g, 20.06 mmol) followed by methanesulfonyl chloride (1.433 ml, 18.39 mmol). After 2 h, the reaction mixture was quenched with aqueous NaHCO3, dried (Na2SO4) and the solvent was removed. MS (ESI) 407 (M+H); Rf=1.69.

1. customthe reaction mixture was quenched with aqueous NaHCO3
2. dry with materialdried (Na2SO4)
3. customthe solvent was removed