Potassium Carbonate → 2,2-Dimethyl-7-pyrimidin-4-yl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one

HRID 132521Notes

Reaction equation

HRID 132521 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7](=O)[CH2:8][C:9]([O:11]CC)=O)=[N:3][CH:2]=1.Br.[CH3:16][C:17]1([CH3:23])[NH:21][C:20]([NH2:22])=[N:19][CH2:18]1.C(=O)([O-])[O-].[K+].[K+]>CO>[CH3:16][C:17]1([CH3:23])[CH2:18][N:19]2[C:9](=[O:11])[CH:8]=[C:7]([C:4]3[CH:5]=[CH:6][N:1]=[CH:2][N:3]=3)[N:22]=[C:20]2[NH:21]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 11961458Ethyl 3-oxo-3-(pyrimidin-4-yl)propanoateHCID 178510605,5-dimethyl-4,5-dihydro-1H-imidazol-2-amine hydrobromide

Product 1

HCID 1358116992,2-Dimethyl-7-pyrimidin-4-yl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture containing 2.09 (10.3 mmol) of ethyl 3-(4-pyrimidinyl)-3-oxopropionate, 2.0 g (10.3 mmol) of 5,5-dimethyl-4,5-dihydro-1H-imidazol-2-ylamine hydrobromide and 2.85 g (20.6 mmol) of potassium carbonate in 15 ml of methanol were heated at reflux temperature during 18 h.

Workup

  1. temperaturewere heated
  2. temperatureat reflux temperature during 18 h.

Sources & evidence

ORD record
ord-7e886ecacba04edcb5e89d9a8ec7f0c7
Source dataset
uspto-grants-2008_06
Patent number
US07388005B2

Reaction notes

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