Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1326262Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1326262
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>CC(C)(C)[O-].COCCOCCOC.CS(C)=O.O=C(O)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1.[Cl][Cu].[Na+]>FC(F)(F)c1ccc(N2CCOCC2)cc1

Komponenten

10

Edukt 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

Produkt 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholineAusbeute 0 %HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholineAusbeute 0 %

Reagenzien, Katalysatoren, Lösungsmittel 5

HCID 23676156Sodium t-butoxideReagenzHCID 62652Cuprous chlorideKatalysatorHCID 1188645142-[3,5-Bis(trifluoromethyl)anilino]-2-oxo-acetic acidKatalysatorHCID 679Dimethyl SulfoxideLösungsmittel5×HCID 8150DiglymeLösungsmittel5×

Reaktionsbedingungen

Temperatur
60 °C

Aufarbeitung

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid-Phase beibehalten
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

Quellen und Nachweise

ORD-Eintrag
ord-7d1b4fcfe103435399620a180ab8e672
Quelldatensatz
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
Originallink
Quelle ansehen

Notizen zur Reaktion

Wird geladen…