反应详情

A mixture of 5.0 g (0.0194 mol) of 4-benzyloxy-3-aminophenyl acetate, 3.3 ml (0.0236 mol) of triethylamine and 3.0 ml (0.0236 mol) of benzenesulphonyl chloride in 150 ml of methylene chloride is stirred at room temperature overnight. The mixture is then washed with water and the organic phase is dried, followed by purification by chromatography on a silica gel column, eluting with a 7/3 cyclohexane/ethyl acetate mixture. The compound of the title is obtained.

1. washThe mixture is then washed with water
2. customthe organic phase is dried
3. customfollowed by purification by chromatography on a silica gel column
4. washeluting with a 7/3 cyclohexane/ethyl acetate mixture
5. customThe compound of the title is obtained