HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 16731996, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Diethyl 2-(3-chloro-4-cyano-2-methylphenyl)malonate | HCID 59734601 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 16731996 | HCID 16731996 | 92.8% |
Reaction Steps
To compound 1F (2.3 g, 7.4 mmol) in 20 mL of MeOH was added 1N NaOH solution (30 mL, 30 mmol), and stirred at RT for 5 hr. It was concentracted, EtOAc was added, then acidified with conc. HCl. The biphase solution was heated at 60° C. for 2 hr, and cooled to RT. The organic layer was separated, dried over Na2SO4, filtered and concentrated to give the title compound (1.44 g). MS (ES) m/z 164 [M-CO2H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07388027B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-cbc7af0a31484382955b496236343866 |
| Source note | uspto-grants-2008_06 |