反应详情

To compound 1F (2.3 g, 7.4 mmol) in 20 mL of MeOH was added 1N NaOH solution (30 mL, 30 mmol), and stirred at RT for 5 hr. It was concentracted, EtOAc was added, then acidified with conc. HCl. The biphase solution was heated at 60° C. for 2 hr, and cooled to RT. The organic layer was separated, dried over Na2SO4, filtered and concentrated to give the title compound (1.44 g). MS (ES) m/z 164 [M-CO2H]−.

1. temperatureThe biphase solution was heated at 60° C. for 2 hr
2. temperaturecooled to RT
3. customThe organic layer was separated
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated