Pyridine → HCID 69198227, compound

HRID 132778Notes

Reaction equation

HRID 132778 reaction equation
[CH2:1]([C:7]1([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:11][CH2:10][CH2:9][CH:8]1[OH:12])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].N1C=CC=CC=1.[C:24](Cl)(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>C(Cl)Cl>[CH2:1]([C:7]1([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:11][CH2:10][CH2:9][CH:8]1[O:12][C:24](=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

5

Reactant 3

HCID 1049PyridineHCID 7412Benzoyl chlorideHCID 69200765HCID 69200765, compound

Product 1

HCID 69198227HCID 69198227, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

12.1 grams of ethyl 1-n-hexyl-2-hydroxy-cyclopentane carboxylate obtained in Example 17 were diluted with 60 ml of methylene chloride. At room temperature and with magnetic stirring, 6.108 ml of pyridine was slowly added, then 8.876 ml of benzoyl chloride was dropwise added. Then the procedure as described in Example 23 was followed, to give 18.16 g of yellow liquid. MS: 346(M+′), 345(M+−1), 301 (M+—OCH2CH3), 273(M+—CO2CH2CH3), 262, 241 (M+−C6H5CO), 225(M+—C6H5CO2), 195, 185, 151, 140, 105 (base), 77.

Sources & evidence

ORD record
ord-8e2cfe9d86714c9cacc9f17ede807901
Source dataset
uspto-grants-2008_06
Patent number
US07388103B2

Reaction notes

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