huagongshe.com
HRID132799

反应详情

EQUATION

反应方程式

HRID 132799 的结构方程式

REACTANTS

反应物

2
反应SMILES：CC(C)(C)OC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H]1CO1
HCID9922319

tert-Butyl {(1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiran-2-yl]ethyl}carbamate

C15H19F2NO3

反应SMILES：C=C[Mg]Br
HCID178418507

未命名化合物

PRODUCTS

产物

1
反应SMILES：C=CC[C@@H](O)[C@H](Cc1cc(F)cc(F)c1)NC(=O)OC(C)(C)C
HCID86591232

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

2 次

PROCEDURE

实验过程

Vinylmagnesium bromide was added to copper (I) bromide-dimethyl sulfide complex in tetrahydrofuran at low temperature. Tert-butyl (1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiran-2-yl]ethylcarbamate (12) in tetrahydrofuran was added. At room temperature, the reaction was quenched with saturated ammonium chloride, extracted, and dried over sodium sulfate. A white solid (13) was obtained upon concentration.

WORKUP

后处理

  1. customAt room temperature, the reaction was quenched with saturated ammonium chloride
  2. extractionextracted
  3. dry with materialdried over sodium sulfate