2,2-Dimethoxypropane → HCID 67562680, compound

HRID 132800Notes

Reaction equation

HRID 132800 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:20]=[C:21]([F:23])[CH:22]=1)[CH2:5][C@H:6]([NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])[C@H:7]([OH:11])[CH2:8][CH:9]=[CH2:10].[NH+]1C=C[CH:27]=[CH:26][CH:25]=1.COC(OC)(C)C>C(Cl)(Cl)Cl>[CH2:8]([C@H:7]1[O:11][C:26]([CH3:27])([CH3:25])[N:12]([C:13]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[C@H:6]1[CH2:5][C:4]1[CH:3]=[C:2]([F:1])[CH:22]=[C:21]([F:23])[CH:20]=1)[CH:9]=[CH2:10]

Participants

5

Reactant 3

HCID 64952,2-DimethoxypropaneHCID 4989215PyridiniumHCID 86591232HCID 86591232, compound

Product 1

HCID 67562680HCID 67562680, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Alcohol 13 was stirred in chloroform with pyridinium p-toulenesulfonate and 2,2-dimethoxypropane while heating to afford (14) as a tan solid after workup.

Workup

  1. temperaturewhile heating

Sources & evidence

ORD record
ord-3d6d0c71fd2141ea97bd0bb8a968db91
Source dataset
uspto-grants-2008_06
Patent number
US07388118B2

Reaction notes

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