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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 132803Generated: October 31, 2026

Di-tert-butyl dicarbonate → Tert-Butyl (2S)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-hydroxyethylcarbamate

https://huagongshe.com/reaction/132803

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDi-tert-butyl dicarbonateHCID 90495—
Reactant(1S)-2-amino-1-[(4r)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanolHCID 59734745—
SolventTetrahydrofuranHCID 8028—
ProductTert-Butyl (2S)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-hydroxyethylcarbamateHCID 14249481—

Reaction Steps

Aminoalcohol 23 was dissolved in THF and BOC2O was added and stirred for several hrs. The solvent was removed and the product purified using silica gel chromatography.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07388118B2
Source datasetuspto-grants-2008_06
ORD IDord-6dacd23111d34dacac13d12d18d78972
Source noteuspto-grants-2008_06