HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 58802797, compound → HCID 71091996, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 58802797 | HCID 58802797 | — |
| Reactant | HCID 178505930 | HCID 178505930 | — |
| Catalyst | HCID 11403411 | HCID 11403411 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 71091996 | HCID 71091996 | — |
Reaction Steps
BOC-Aziridine (21), copper bromide-dimethyl sulfide (0.15 eq.), and THF were cooled to −20° and (3,5-difluorophenyl)magnesium bromide (1.25 eq.) in THF was added. The reaction was allowed to warm to 200 and stir overnight. The reaction was extracted and the solvent removed to afford the crude product (26) as a syrup.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07388118B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-9f7a50fe966a4effb10fd8fb00c3f23c |
| Source note | uspto-grants-2008_06 |