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HRID132805

反应详情

EQUATION

反应方程式

HRID 132805 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)N1C[C@H]1[C@H]1COC(C)(C)O1
HCID58802797

未命名化合物

结构：Fc1cc(F)cc([Mg]Br)c1
HCID178505930

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H]1COC(C)(C)O1
HCID71091996

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CSC.[Br][Cu][Br]
催化剂HCID11403411

未命名化合物

结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

2 次

PROCEDURE

实验过程

BOC-Aziridine (21), copper bromide-dimethyl sulfide (0.15 eq.), and THF were cooled to −20° and (3,5-difluorophenyl)magnesium bromide (1.25 eq.) in THF was added. The reaction was allowed to warm to 200 and stir overnight. The reaction was extracted and the solvent removed to afford the crude product (26) as a syrup.

WORKUP

后处理

  1. temperatureto warm to 200
  2. extractionThe reaction was extracted
  3. customthe solvent removed