HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (3S)-3-(piperidine-1-carbonyl)-1,2,3,4-tetrahydroisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (3S)-2-((tert-butoxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid | HCID 664088 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | (3S)-3-(piperidine-1-carbonyl)-1,2,3,4-tetrahydroisoquinoline | HCID 10657955 | — |
Reaction Steps
Following a procedure similar to that described for Intermediate 14, treatment of Boc-TIC-OH with EDC, HOBt, N,N-diisopropylethylamine and piperidine, followed by deprotection using trifluoroacetic acid, afforded the title compound as a white foam. LC/MS: 245.2 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07388019B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-e1fd4f18821741ddab6a8ef7d71ad754 |
| Source note | uspto-grants-2008_06 |