HCID 58687990, compound → HCID 69222706, compound

HRID 132852Notes

Reaction equation

HRID 132852 reaction equation
C([NH:14][CH2:15][CH2:16][C:17]1[C:18]([O:36][CH3:37])=[N:19][C:20]([C:32]([F:35])([F:34])[F:33])=[CH:21][C:22]=1[CH2:23][O:24][Si:25]([C:28]([CH3:31])([CH3:30])[CH3:29])([CH3:27])[CH3:26])(C1C=CC=CC=1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[Si:25]([O:24][CH2:23][C:22]1[CH:21]=[C:20]([C:32]([F:35])([F:34])[F:33])[N:19]=[C:18]([O:36][CH3:37])[C:17]=1[CH2:16][CH2:15][NH2:14])([C:28]([CH3:31])([CH3:30])[CH3:29])([CH3:27])[CH3:26]

Participants

5

Reactant 2

HCID 58687990HCID 58687990, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 69222706HCID 69222706, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of the compound from Step I above (1.25 g, 2.36 mmol) in absolute ethanol (100 mL) was added 10% palladium on carbon (480 mg). The reaction mixture was placed in a Parr apparatus and shaken under 50 psi of hydrogen for 4 hours. The solution was filtered through a pad of Celite and concentrated in vacuo to yield the title compound. LC/MS: 365 (M+1).

Workup

  1. filtrationThe solution was filtered through a pad of Celite
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-608e0fd9976d4bd0b00f241b3933b2b9
Source dataset
uspto-grants-2008_06
Patent number
US07388019B2

Reaction notes

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